Sildenafil and Tadalafil belong to PDE5 inhibitors. They improve the flow of blood to the penile area due to the influence on the smooth muscles of the blood vessels. They relax and let the cavernous bodies of the penis fill with blood. It helps to get a firm and durable erection. Yet the pills themselves cannot make the penis erected: a man needs to feel sexual arousal to get the effect.
Both preparations have a common mechanism of action though the onset and the durability of their impact differ. Besides, they have the same contraindications to usage:
- Intake of nitrate-containing drugs (for example for angina treatment);
- Heart ailments like arrhythmia, pain in chest and heart failure;
- Uncontrolled hypertension or too low blood pressure;
- Allergy to any active or inactive component of the drug;
- A stroke or a heart attack in the last 6 months.
What is sildenafil?
Sildenafil is a generic version of the famous brand pills Viagra. It has proved its efficiency long ago and is widely used by millions of men around the world. It starts working in 30-60 minutes after the intake. For the best effect it is recommended to take a tablet approximately an hour prior to the anticipated sexual intercourse. To get quick results sildenafil should be taken on an empty stomach. If taken with a fatty meal, the beginning of its action may be delayed up to 1.5-3 hours. This drug is not intended for daily use. The pill stays effective for 4-6 hours.
What is tadalafil?
Tadalafil is known under the brand name Cialis. It stands out of other ED pills due to its period of action, which lasts up to 36. The onset of action of this drug doesn’t depend on meals and starts in 20-30 minutes after the intake. Tadalafil may be taken in two ways, either before a planned sexual intercourse, or daily. Depending on your choice the dosing regimen of the drug varies: from 5mg to 20mg (pends on the patient’s tolerance) if taken before sex and 2.5mg-5mg if taken daily.
Sildenafil and tadalafil combination
The pill, which joined sildenafil and tadalafil together is called Sildalis. This drug has sildenafil citrate 100mg and tadalafil 20mg in its composition. Hence, all the best qualities of both medications are present in one tablet.
Sildalis pills start acting within 15-30 minutes after the intake provided that a man feels sexual arousal. The maximal continuance of its effect is about 36 hours. The patient should take not more than one pill within 24 hours.
The intake of Sildalis may provoke a number of unwanted reactions, which go away in approximately 2 hours:
- Nasal congestion;
- Muscle pain or back pain;
- Dizziness, nausea, heartburn, diarrhea;
In some very rare cases there might develop conditions, which demand medical help:
- Priapism (painful erection lasting more than 4 hours);
- Vision problems.
Alcohol and grapefruit juice should be avoided during the intake of either ED drug because their combination may influence the action of medications and cause serious side effects.